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| First Name: | Elaine L. | | Last Name: | Bearer | | Title: | Harvey Family Professor and Vice Chair for Research | | Advanced Degrees: | Md, Phd | | Affiliation: | University of New Mexico | | Department: | Pathology | | Street Address 1: | BMSB 333 | | City: | Albuquerque | | State/Province: | NM | | Zip/Postal Code: | 87122 | Country/Territory: | U.S.A. | | Phone: | 505-272-9725 | | Email Address: |  |
Disclosure:
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Member reports no financial or other potential conflicts of interest. [Last Modified: 19 February 2011]
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View all comments by Elaine L. Bearer
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Neuromuscular Disorders (ALS, etc.), Aging Process, Stroke and Trauma, Parkinson Disease, Alzheimer Disease, Neurodevelopmental Disorders (Down syndrome, etc.), Tauopathies, Polyglutamine Disorders (Huntington's, etc.)
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Microscopy, Animal Models, Neuropathology, Brain imaging, Transport and Tract tracing, A-beta PP/A-beta, Diagnosis, Neurobiology, Tau/Cytoskeleton, Molecular and Cell biology, Stem cells, Genetics
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Bearer holds both MD and PhD from UCSF. After residency and fellowships she was recruited to Brown University as a tenure-track professor. In 2009 she joined University of New Mexico as teh Harvey Family Endowed Professor and Vice Chair for Research in the Dept of Pathology. Her work focuses on the molecular and cellular mechanisms of intracellular transport with emphasis on those processes that when abnormal cause disease. She discovered the cellular link between herpes virus and amyloid precursor protein (APP), and how interactions between virus and APP lead to mal-distribution of APP inside cells, a mechanistic insight into the role of HSV in Alzheimer's disease. |
1. Cheng, SB, Ferland, P, Webster, P, and Bearer E.L. Herpes simplex virus dances with amyloid precursor protein while exiting the cell (accepted for publications, PLoS ONE Feb. 18, 2011)
2. Brown, WD, Bearer, E.L., and Donohue, JE (2010) Chronic active herpes simplex type 2 in an asymptomatic immunocompetent child. J. Child. Neurol. 25(7):901-8. Epub 2010 Feb 22. PMID: 20179002.
3. Bearer, E.L., Zhang X, Janvelyan D, Boulat B, Jacobs RE. (2009) Reward circuitry is perturbed in the absence of the serotonin transporter. NeuroImage. 2009 Jul 15;46(4):1091-104. Epub 2009 Mar 20. PMID: 19306930.
4. Bearer, E.L., Lowengrub JS, Chuang YL, Frieboes HB, Jin F, Wise SM, Ferrari M, Agus DB, Cristini V. (2009) Multidimensional Computational Modeling of Tumor Invasion. Cancer Res. 69(10):4493-501. Epub 2009 Apr 14. PMID: 19366801
5. Cui B, Wu C, Chen L, Ramirez A, Bearer, E.L., Li WP, Mobley WC, Chu S. (2007) One at a time, live tracking of NGF axonal transport using quantum dots. Proc Natl Acad Sci U S A. 104:13666-71. PMID: 17698956
6. Bearer, E.L., Zhang, X.W. and Jacobs, R.E. (2007) Live imaging of neuronal connections by magnetic resonance: Robust transport in the hippocampal-septal memory circuit in a mouse model of Down syndrome. NeuroImage, 37: 232-240. PMID: 17566763
7. Bearer, E.L., Falzone, T.L., Zhang, X.W., Biris, O, Rasin, A, Jacobs, R.E. (2007) Role of neuronal activity and kinesin on tract tracing by manganese-enhanced MRI (MEMRI) Neuroimage. 2007;37 Suppl 1:S37-46. PMID: 17600729
8. Satpute-Krishnan, P., DeGiorgis, JA, Conley, MI, Jang, M, and Bearer, E.L. (2006) A peptide zipcode sufficient for anterograde transport within amyloid precursor protein. Proc. Nat. Acad. Sci103(44):16532-7. PMID: 17062754
9. Satpute-Krishnan, P., DeGiorgis, J.A., and Bearer, E.L. (2003) Fast Anterograde Transport of Herpes Virus: Role for the Amyloid Precursor Protein of Alzheimer's Disease. Aging Cell 2(6): 287-294. PMID: 14677633
10. Bearer, E.L. Breakefield, X.O., Schuback, D., Reese, T.S. and LaVail, J.H. (2000) Retrograde axonal transport of Herpes Simplex Virus: Evidence for a single mechanism and a role for tegument. Proc. Natl. Acad. Sci. USA, 97: 8146-8150. PMID: 10884436
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Role of transport and impact of infectious disease, both inflammatory cytokines and neurotropic viruses. |
Zamecnik, J. 2005. The extracellular space and matrix of gliomas. Acta Neuropathol. 110:435-442.
Zimmermann, D.R., and M.T. Dours-Zimmermann. 2008. Extracellular matrix of the central nervous system: from neglect to challenge. Histochem Cell Biol. 130:635-653.
Shah, N., B. Lin, Z. Sibenaller, T. Ryken, H. Lee, J.G. Yoon, S. Rostad, and G. Foltz. 2011. Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM. PLoS One. 6:e16146. |
Magnetic resonance imaging (MRI) of brain circuitry and transport dynamics in mouse models of neurodegeneration and psychiatric disease with clinical correlations in humans, using targeted genetic screening, genome-wide association data, fMRI and DTI. |
that axonal transport defects in selected regions of the brain underlie mental and neural dysfunction, are caused by both intrinsic (genetic) and extrinsic (infectious, environmental toxin) forces, and can be detected early in disease processes by MR and gene testing. |
the ability to image axonal transport in the CNS and correlate dysfunction with underlying causes--ie information about axonal transport in the living brain. |
Role of Matrix protease in specifying axonal connections, synapse remodeling and neuronal surivial, |
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